Protein carbonylation process

Protein carbonylation is an irreversible oxidative post-translational modification in which proteins acquire reactive carbonyl groups (aldehydes, ketones) after exposure to reactive oxygen species, lipid peroxidation products, or reactive sugars via glycation[1][2][3][4]. These modifications alter protein structure and function, marking them for degradation and contributing to cellular aging, chronic disease, inflammatory processes, and oxidative stress conditions[2][3][4][5]. Carbonylated proteins and their levels serve as biomarkers of oxidative damage and stress; they are detectable via specific assays and may be targeted by antioxidants or carbonyl scavengers in therapeutic research[1][3][5].

Other names

Protein carbonylationProtein oxidation (by reactive carbonyls)Advanced glycation end-products (AGE) formation (when glycation is involved)Carbonyl stress

Scavenging reactive carbonyl species to prevent protein modification\nInhibiting glycation or oxidative pathways producing carbonyls