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Target intelligence / Profile preview
Protein Disulfide-Isomerase (PDI)
- Target
- PDI
- Molecular classification
- Enzyme, Oxidoreductase, Chaperone
01
Overview
Protein disulfide-isomerase (PDI) is a multifunctional enzyme primarily located in the endoplasmic reticulum (ER) of eukaryotic cells. It plays a central role in catalyzing the formation, reduction, and isomerization of disulfide bonds during protein folding, ensuring correct protein conformation and quality control. PDI also exhibits chaperone activity by preventing aggregation of misfolded proteins and directing them for degradation if proper folding cannot be achieved. It is implicated in several diseases including neurodegenerative disorders, cancer and viral infections.
02
Mechanism of action
Catalyzes the formation, reduction, and isomerization of disulfide bonds in proteins.
03
Biological functions
Protein foldingDisulfide bond formation/reduction/isomerizationProtein quality controlChaperone activityImmune responseViral entry
04
Disease associations
Neurodegenerative diseaseCancer progressionInfectious disease facilitation
05
Safety considerations
Potential for off-target effects due to broad substrate specificity.Inhibition may disrupt protein homeostasis.
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