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Target intelligence / Profile preview
Protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P1)
- Target
- PDIA3P1
- Molecular classification
- Other (Pseudogene)
01
Overview
Protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P1), also known as GRP58P, is a non-coding pseudogene. Unlike the protein-coding gene PDIA3, which encodes the multifunctional protein disulfide isomerase ERp57/GRP58 (involved in endoplasmic reticulum quality control, chaperone activity, and immune regulation[3]), PDIA3P1 lacks protein-coding capability and does not produce a functional protein. Although it is catalogued in gene databases and sometimes listed in disease association screens, its biological impact (if any) occurs through non-coding RNA effects or sequence homology rather than direct molecular function. It is not considered a therapeutic target, receptor, enzyme, or transporter[4]. Any medically relevant activity is specific to the related protein-coding gene PDIA3, not PDIA3P1.
- Other names
- GRP58PGlucose regulated protein, 58kDa pseudogene
02
Mechanism of action
None (not a drug target)
03
Biological functions
None (pseudogenes do not produce functional protein; see description for context)
04
Disease associations
Potential association with "Lung Non-Small Cell Carcinoma" (listed as associated disease, but as a pseudogene, clinical significance typically comes from nearby genes or regulatory effects rather than direct function)[4]
05
Safety considerations
None (pseudogene, not a therapeutic target)
06
Interacting drugs
None (no drugs target PDIA3P1 directly; active protein-coding PDIA3 has more relevance as a drug target)
07
Biomarkers
None reported for PDIA3P1 itself
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