Protein disulfide-isomerase A4 (PDIA4)

Protein disulfide-isomerase A4 (PDIA4) is an enzyme that functions as a chaperone in the endoplasmic reticulum (ER). It catalyzes the formation, breakage, and rearrangement of disulfide bonds during protein folding. PDIA4 has been implicated in several disease processes including tumorigenesis, angiogenesis, and therapy resistance in cancers. It also interacts with viral proteins during microbial infection. Inhibitors targeting this enzyme are under investigation for their ability to disrupt aberrant protein folding or stress responses associated with malignancy or infection.

Other names

ERp72Protein disulfide-isomerase family A member 4

Inhibition of protein folding, disruption of aberrant protein folding or stress responses