Protein Disulfide Isomerase Family Proteins (PDI family)

Protein disulfide isomerases (PDIs) are a family of enzymes primarily responsible for catalyzing the formation, breakage, and rearrangement (isomerization) of disulfide bonds in proteins. These processes are essential for proper protein folding and stability, particularly within the endoplasmic reticulum (ER) of eukaryotic cells. PDIs also possess chaperone activity, assisting in the correct folding or degradation of misfolded proteins. The human PDI gene family comprises 21 genes with diverse domain compositions and functions. Given their central role in proteostasis networks—especially UPR—PDIs have emerged as promising drug targets for conditions like cancer, neurodegeneration, diabetes, liver disease, and thrombosis.

Other names

PDIProtein disulfide isomerase

Inhibition of disulfide bond formation/isomerization, disruption of protein folding and ER homeostasis