Target intelligence / Profile preview

Protein Disulphide Isomerase (PDI)

Target: PDI
Molecular classification: Enzyme, Chaperone, Redox enzyme, Isomerase

Overview

Protein disulphide isomerase is an essential redox enzyme responsible for ensuring correct folding/stability via management of cysteine-based crosslinks within polypeptides. Its versatile functions extend from basic proteostasis maintenance to specialized roles at different cellular locations—including implications for disease states such as cancer—making it both biologically fundamental and clinically significant as a therapeutic target.

Mechanism of action

Thiolate-mediated nucleophilic attack/disulphide exchange

Biological functions

Protein foldingDisulfide bond formationDisulfide bond isomerizationChaperone activityImmune responseER stress response

Disease associations

CancerHIV infectionDiseases linked to improper protein folding

Safety considerations

Inhibitors not clinically approved yetOptimization of inhibitors needed

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