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Target intelligence / Profile preview
Protein E7
- Molecular classification
- Oncoprotein, Viral protein
01
Overview
Protein E7 is an oncoprotein encoded by high-risk human papillomaviruses (HPVs), such as HPV16 and HPV18. It disrupts normal cell cycle control by binding to and degrading retinoblastoma protein (pRb), leading to uncontrolled cell proliferation and cancer development. E7 also induces genomic instability, inhibits apoptosis, evades immune responses, and interacts with other viral proteins to promote oncogenesis. It is a target for therapeutic vaccines and small molecule inhibitors.
- Other names
- E7 oncoproteinHPV16 E7HPV18 E7
02
Mechanism of action
Therapeutic vaccines generate anti-tumor immunity; small molecule inhibitors targeting E7 function are in development.
03
Biological functions
Cell cycle deregulationpRb degradationS-phase entry promotionGenomic instability inductionApoptosis inhibitionImmune evasionTranscription regulation
04
Disease associations
CancerCervical cancerAnogenital cancersInfection
05
Safety considerations
Potential for off-target effects with inhibitorsImmune-related adverse events with vaccines
06
Biomarkers
E7 antibody levelsE7-specific T-cell responses
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