Protein ecdysoneless homolog (ECD)

Protein ecdysoneless homolog (ECD) is a highly conserved human protein essential for cell cycle progression and cell survival, acting primarily by modulating the Rb–E2F pathway and directly binding to p53, thereby affecting its stability and function[1][3][4][5]. ECD is also a novel RNA-binding protein critical for the biogenesis and function of the U5 small nuclear ribonucleoprotein (snRNP), thus regulating pre-mRNA splicing fidelity and integrity[2][3]. Overexpression of ECD has been linked to cancer progression and poor prognosis, notably in head and neck and cervical cancers, while its ablation impairs cell proliferation and splicing, highlighting both its fundamental biologic role and its potential as a future therapeutic target[1][2][3][4][5].

Other names

Human suppressor of GCR twoGCR2SGT1hSGT1HSGT1Protein SGT1Ecdysoneless homologSuppressor of GCR2Suppressor of S. cerevisiae GCR2Ecd

Not applicable (no drugs currently target ECD directly; its biological role is mainly via protein and RNA interactions[1][2][3])