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Protein EFR3 homolog A (EFR3A)
- Target
- EFR3A
- Molecular classification
- Peripheral membrane protein, Complex assembly factor
01
Overview
Protein EFR3 homolog A is a peripheral membrane protein essential for the localization and function of the PI4KA complex at the plasma membrane, which regulates the synthesis of critical signaling lipids. EFR3A’s roles include controlling cellular responses to GPCRs, organizing RAS nanoclusters for oncogenic signaling, and modulating insulin-stimulated glucose transport. Mutations and dysregulation of EFR3A have been linked to autism spectrum disorders, cancers, and cardiovascular disease, indicating a broad though currently indirect pathophysiological relevance. While pivotal in membrane lipid signaling and cellular homeostasis, EFR3A is not a direct drug target or biomarker in clinical practice.
- Other names
- EFR3AKIAA0143Protein EFR3-likeprotein EFR3 homolog A
02
Biological functions
Plasma membrane localization of PI4KA complexRegulation of PI4P and PI(4,5)P₂ synthesisRegulation of G protein-coupled receptor (GPCR) responsivenessControl of insulin-stimulated glucose transportAssembly of oncogenic RAS nanoclusters
03
Disease associations
Neurological disorders (e.g., autism spectrum disorder)Developmental malformations-deafness-dystonia syndromeCancer (colorectal, pancreatic, glioma)Cardiovascular disease
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