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Target intelligence / Profile preview
Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha (FNTA)
- Target
- FNTA
- Molecular classification
- Enzyme, Prenyltransferase, Transferase Subunit
01
Overview
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) is a critical subunit shared by both farnesyltransferase (FTase) and geranylgeranyltransferase type I (GGTase-I) enzymes. These enzymes catalyze the transfer of farnesyl or geranylgeranyl lipid moieties to proteins, primarily at C-terminal CAAX motifs, facilitating membrane association and downstream signaling events. FNTA plays a crucial role in regulating the localization and activity of key signaling proteins, including Ras family members, impacting cell growth, differentiation, and oncogenesis. It interacts with TGF beta receptor 1. Inhibitors targeting the activity of FNTA-containing complexes are explored as anti-cancer therapies.
- Other names
- Type I protein geranyl-geranyltransferase subunit alphaRas proteins prenyltransferase subunit alphaFTase-alphaCAAX farnesyltransferase subunit alphaPGGT1APTAR2
02
Mechanism of action
Inhibition of farnesyltransferase or geranylgeranyltransferase activity
03
Biological functions
Protein prenylationMembrane associationSignal transductionNeuromuscular junction developmentLipid modification
04
Disease associations
Cancer
05
Safety considerations
Off-target effects due to broad substrate specificity of FTases/GGTasesPotential for drug resistance development
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