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Protein fem-1 homolog C (FEM1C)
- Target
- FEM1C
- Molecular classification
- E3 ubiquitin ligase substrate adaptor, Component of Cul2-RING E3 ubiquitin ligase complex
01
Overview
Protein fem-1 homolog C (FEM1C) is a substrate-recognition component of the Cul2-RING E3 ubiquitin ligase complex, specifically functioning in the DesCEND pathway that mediates the ubiquitination and degradation of proteins possessing a C-terminal degron, often an arginine motif. FEM1C is located in the cytosol and nucleus and plays a role in cellular protein quality control and turnover. FEM1C mutations have been associated with familial adenomatous polyposis and rare neurodevelopmental disorders. There are no approved drug therapies targeting FEM1C, and it is not currently considered a canonical drug target in clinical pharmacology.
- Other names
- FEM1CKIAA1785EUROIMAGE686608EUROIMAGE783647FEM1-gammaprotein fem-1 homolog C
02
Mechanism of action
not applicable (no characterized drugs targeting FEM1C directly)
03
Biological functions
Ubiquitin-dependent protein catabolic processSubstrate recognition for protein ubiquitination and degradation (particularly C-end degron pathway)Regulation of stem-loop binding protein turnoverPossibly involved in protein quality control in cytosol and nucleoplasm
04
Disease associations
Familial adenomatous polyposisVariant implicated in neurodevelopmental disorder (novel cases linking FEM1C mutations to disease phenotypes)
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