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Target intelligence / Profile preview
Protein Geranylgeranyltransferase-I (GGTase-I)
- Target
- GGTase-I
- Molecular classification
- Enzyme, Prenyltransferase
01
Overview
Protein geranylgeranyltransferase-I (GGTase-I) is an essential enzyme in eukaryotes that catalyzes the transfer of a 20-carbon isoprenoid lipid (geranylgeranyl group) to the sulfur atom of a cysteine residue located near the C-terminus of target proteins. This post-translational modification, prenylation, is crucial for the membrane association and proper function of many signaling proteins, particularly small GTPases. GGTase-I is a heterodimer composed of alpha and beta subunits and is a therapeutic target for cancer, infectious diseases, and other disorders.
02
Mechanism of action
Inhibition of geranylgeranyl group transfer to target proteins
03
Biological functions
Post-translational modificationProtein prenylationLipid modificationSignal transductionMembrane association
04
Disease associations
CancerInfectious DiseasesDevelopmental Disorders
05
Safety considerations
Potential for off-target effects due to similarity to other prenyltransferasesToxicity related to disruption of essential cellular processes
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