Protein geranylgeranyltransferase type I subunit beta (GGTase-I beta)

Protein geranylgeranyltransferase type I subunit beta is part of an enzyme complex that catalyzes the transfer of a geranylgeranyl group from geranylgeranyl diphosphate to cysteine on proteins with a C-terminal CAAX motif. This process is crucial for the proper functioning of many signal transduction proteins involved in growth and differentiation. The enzyme is heterodimeric, consisting of alpha and beta subunits, and is a key player in the post-translational modification of proteins, affecting their membrane association and biological activity.

Other names

Type I protein geranyl-geranyltransferase subunit betaGGTIBGGIPGGT1B

Inhibition of geranylgeranyltransferase activity to prevent prenylation of proteins, which can disrupt signaling pathways crucial for disease progression.