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Target intelligence / Profile preview
Protein-glutamine gamma-glutamyltransferase 2 (TGM2)
- Target
- TGM2
- Molecular classification
- Enzyme, Acyltransferase, Transglutaminase
01
Overview
Protein-glutamine gamma-glutamyltransferase 2 (TGM2) is a multifunctional enzyme known for its role as a calcium-dependent acyltransferase. It catalyzes protein cross-linking and post-translational modifications like serotonylation and dopaminylation. It participates in various biological processes including bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification, and apoptosis. TGM2 is found in multiple cellular compartments, including the cytoplasm, nucleus, plasma membrane, and extracellular matrix.
- Other names
- Transglutaminase-2Transglutaminase HTransglutaminase CTissue transglutaminase
02
Mechanism of action
Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between glutamine and primary amines, leading to protein cross-linking and post-translational modifications.
03
Biological functions
Protein cross-linkingPost-translational modificationBone developmentAngiogenesisWound healingCellular differentiationChromatin modificationApoptosis
04
Disease associations
CancerInflammationNeurodegenerative diseaseCardiovascular diseaseFibrosis
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