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Target intelligence / Profile preview
Protein-glutamine gamma-glutamyltransferase 4 (TGM4)
- Target
- TGM4
- Molecular classification
- Enzyme, Transferase
01
Overview
Protein-glutamine gamma-glutamyltransferase 4 (TGM4) is an enzyme primarily expressed in the prostate, where it catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins, processes associated with seminal plug formation and the mammalian reproductive process. TGM4 is being investigated as a biological factor and potential biomarker for the diagnosis and prognosis of prostate cancer. Its molecular function falls under protein-glutamine gamma-glutamyltransferase activity, and its gene (TGM4) is located on human chromosome 3[1][3][5][6].
- Other names
- FibrinoligaseProstate transglutaminaseProstate-specific transglutaminaseTG(P)TGase PTGase-4TGPhTGPTransglutaminase PTransglutaminase-4
02
Mechanism of action
Enzyme inhibition (inferred, since it is an enzyme; specific inhibitors not reported in provided sources)
03
Biological functions
Protein cross-linkingPolyamine conjugation to proteinsInvolvement in seminal plug formationMammalian reproductive process
04
Disease associations
Cancer (notably prostate cancer)Essential tremorAutoimmune polyendocrine syndrome type 1
05
Safety considerations
Potential off-target effects if targeted therapeutically (inferred; specific safety challenges not reported in available search results)
06
Biomarkers
Diagnostic and prognostic biomarker for prostate cancer[5]
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