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Protein hinderin (gene symbol KIAA1328) is a human protein that competes with the structural maintenance of chromosomes protein SMC1 for binding to SMC3. This competition may regulate the availability of SMC3 for the assembly of multimeric protein complexes involved in chromosome maintenance and dynamics. The protein is primarily defined by its protein-binding function and does not belong to major molecular families such as receptors, enzymes, ion channels, or transporters. No therapeutic drugs, biomarker uses, or established safety concerns have been identified for this protein, and its precise biological or disease role remains insufficiently characterized.
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