Protein kinase, cAMP-dependent, regulatory subunit type II beta pseudogene

Protein kinase, cAMP-dependent, regulatory subunit type II beta pseudogene (ENSG00000255381) is a genomic DNA sequence similar to the functional PRKAR2B gene but is classified as a pseudogene, meaning it does not produce a functional protein product. Pseudogenes generally arise from duplication or retrotransposition events and are non-functional; they are not typically involved in drug targeting, disease association, or cellular signaling. This distinguishes it from the functional PRKAR2B gene, which encodes a regulatory subunit of protein kinase A and is important in cAMP signaling, energy balance, and other processes[1][2][3]. The PRKAR2B pseudogene is not a therapeutic target, receptor, enzyme, transporter, or regulator in the sense relevant to pharmacology or disease. If the intention was to refer to the functional protein PRKAR2B (protein kinase, cAMP-dependent, regulatory subunit type II beta), that is a recognized signal transduction enzyme with disease associations and therapeutic implications[1][4][7]. However, ENSG00000255381 is explicitly a pseudogene and not functionally equivalent to PRKAR2B.

Other names

protein kinase, cAMP-dependent, regulatory, type II, beta pseudogenePRKAR2B pseudogeneLOC100422399