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Protein kinase, Y-linked (pseudogene) (PRKY)
- Target
- PRKY
- Molecular classification
- Other (Pseudogene; similar to serine/threonine protein kinase family, but does not encode a functional protein)
01
Overview
Protein kinase, Y-linked (PRKY) is a human gene on the Y chromosome, highly similar to the protein kinase, X-linked (PRKX) gene. PRKY is classified as a transcribed pseudogene because it has lost a coding exon, causing all transcripts to undergo nonsense-mediated decay and preventing the expression of a functional protein[1][4][5]. Abnormal recombination between PRKY on the Y chromosome and PRKX on the X chromosome is a frequent cause of XX males and XY females, implicating PRKY in some sex reversal syndromes[1][6]. Although gene expression or methylation status of PRKY may be relevant for cancer diagnostics, it is not considered a classical protein target for drugs or biologics[1][4][5][9].
- Other names
- PRKXP3PRKYPPRKYP3PRKY
02
Mechanism of action
Null (no targeted drugs or mechanisms defined)
03
Biological functions
None (No documented functional protein product)May be involved in abnormal chromosomal recombination events leading to XX males and XY females
04
Disease associations
Sex reversal disorders (XX males, XY females) caused by abnormal recombination with the homologous gene on chromosome XReported association with oncocytic carcinoma of the thyroid and as a diagnostic biomarker in prostate cancer (by methylation)
05
Safety considerations
None specific to therapeutics (not a druggable target).Possible diagnostic or genetic counseling implications for chromosomal disorders due to recombination events
06
Interacting drugs
None reported (no functional protein product or therapeutic targeting known)
07
Biomarkers
Promoter hypermethylation of PRKY gene has been proposed as a potential biomarker for early prostate cancer diagnosis
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