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Target intelligence / Profile preview
Protein Kinase A Regulatory Subunit Type I Alpha (RIα)
- Target
- RIα
- Molecular classification
- Regulatory subunit, Protein kinase A subunit, Scaffolding protein
01
Overview
The Protein Kinase A (PKA) RIα regulatory subunit controls PKA activity by binding to catalytic subunits and inhibiting them. Binding of cAMP to RIα releases the catalytic subunits, activating PKA. RIα also interacts with AKAPs to localize PKA to specific cellular compartments, enabling spatial-temporal control of signaling. Mutations in PRKAR1A are associated with Carney complex, a multiple neoplasia syndrome.
- Other names
- PRKAR1APKA regulatory subunit RIalphaPKARIα
02
Mechanism of action
Inhibits catalytic subunit of PKA in the absence of cAMP; releases catalytic subunit upon cAMP binding.
03
Biological functions
Regulation of protein kinase activitycAMP bindingA-kinase anchoring protein (AKAP) bindingSignal transductionRegulation of cellular metabolism
04
Disease associations
Carney complexCancerEndocrine disorders
05
Safety considerations
Potential for off-target effects due to widespread expressionModulation of PKA activity can have pleiotropic effects
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