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Protein kinase AMP-activated non-catalytic subunit beta 1 (None)
- Target
- None
- Molecular classification
- Regulatory subunit, Adaptor protein
01
Overview
Protein kinase AMP-activated non-catalytic subunit beta 1 is a regulatory component of the heterotrimeric AMP-activated protein kinase (AMPK) complex. The AMPK complex consists of a catalytic alpha (α) subunit and two regulatory subunits: beta (β) and gamma (γ). PRKAB1 encodes the β₁ isoform of the non-catalytic beta subunit in humans. It acts as a positive regulator and adaptor within the AMPK complex, facilitates assembly, and contains a glycogen-binding domain. Myristoylation and phosphorylation of this subunit modulate enzyme activity and localization. It may influence energy homeostasis through modulation of fatty acid and cholesterol biosynthesis.
- Other names
- PRKAB1AMPKB1AMPK beta 1protein kinase AMP-activated beta 1 non-catalytic subunit
02
Mechanism of action
Modulation of AMPK activity and localization; regulation of downstream targets such as ACC and HMG-CoA reductase.
03
Biological functions
Energy sensingRegulation of AMPK complexRegulation of fatty acid biosynthesisRegulation of cholesterol biosynthesisGlycogen bindingModulation of enzyme activityRegulation of cellular metabolism
04
Disease associations
Metabolic diseasesObesityDiabetes mellitus type IICardiovascular diseaseInflammation
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