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Target intelligence / Profile preview
Akt Serine/Threonine-Protein Kinase (Akt)
- Target
- Akt
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase
01
Overview
Akt, also known as Protein Kinase B (PKB), is a serine/threonine-specific protein kinase that plays a central role in multiple cellular processes, including metabolism, cell proliferation, survival (anti-apoptosis), growth, and angiogenesis. It is a key component of the PI3K/Akt/mTOR signaling pathway and is activated in response to growth factors or insulin. Dysregulation or hyperactivation of Akt has been implicated in various diseases including cancer, diabetes, and inflammatory disorders.
- Other names
- Protein Kinase BPKBRAC-alpha serine/threonine-protein kinaseAKT1AKT2AKT3
02
Mechanism of action
Akt inhibitors block the activity of Akt kinases, leading to decreased cell proliferation, increased apoptosis, and inhibition of angiogenesis.
03
Biological functions
Cell survivalCell cycle progressionMetabolismLysosomal biogenesisAutophagyAngiogenesisCell proliferationGrowth
04
Disease associations
CancerDiabetesInflammatory disordersHepatocarcinogenesisBreast cancer progressionOsteosarcopeniaFibrosis associated with liver disease
05
Safety considerations
Potential for off-target effects due to the broad range of Akt substratesDevelopment of resistance mechanisms in cancer cellsUnintended consequences of inhibiting Akt signaling in normal tissues
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