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Target intelligence / Profile preview
Protein Kinase C (PKC)
- Target
- PKC
- Molecular classification
- Enzyme, Serine/Threonine Kinase
01
Overview
Protein kinase C (PKC) refers to a family of serine/threonine kinases that play crucial roles in cellular signaling. PKCs phosphorylate target proteins on serine and threonine residues, thereby regulating diverse cellular processes such as cell proliferation, gene expression, differentiation, immune responses, and the cell cycle.
- Other names
- PKC familyEC 2.7.11.13
02
Mechanism of action
PKCs phosphorylate target proteins on serine and threonine residues, thereby regulating diverse cellular processes.
03
Biological functions
Signal transductionCell proliferationGene expression regulationProtein secretionImmune responseCell cycle progressionMemory formation
04
Disease associations
CancerNeurodegenerative diseaseInflammationOther
05
Safety considerations
Complexity of isoform-specific functionsChallenges in therapeutic targeting
06
Interacting drugs
Phorbol esters
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