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Target intelligence / Profile preview
Protein kinase C alpha (PKCα)
- Target
- PKCα
- Molecular classification
- Protein kinase C (PKC) family, AGC serine/threonine kinases, Enzyme
01
Overview
Protein kinase C alpha (PKCα) is a serine/threonine kinase involved in diverse cellular signaling pathways. It is activated by calcium ions (Ca²⁺), diacylglycerol (DAG), and phosphatidylserine, leading to translocation from the cytosol to cellular membranes. PKCα regulates cell proliferation, apoptosis, differentiation, motility/migration, inflammation, and cardiac contractility. Its effects are cell-type dependent, and selective targeting poses therapeutic challenges due to its ubiquitous expression and multifunctional roles.
- Other names
- PRKCA
02
Mechanism of action
Phosphorylates serine/threonine residues on target proteins to modulate their function
03
Biological functions
Regulation of cell proliferationApoptosisDifferentiationMotility/migrationInflammationCell adhesionCell transformationCell cycle checkpoint controlCardiac contractilityCa²⁺ handling
04
Disease associations
Cardiac contractility disordersAtherogenesisCancer progressionArterial thrombosis
05
Safety considerations
Widespread expression and multifunctional roles may complicate selective targetingCell-type dependent effects of activation or overexpression
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