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Target intelligence / Profile preview
Protein kinase C alpha type (PKCα)
- Target
- PKCα
- Molecular classification
- Enzyme, Serine/threonine kinase, Protein kinase C (PKC) family, Conventional PKC isoform (cPKC)
01
Overview
Protein kinase C alpha (PKCα) is a serine/threonine kinase belonging to the PKC family of enzymes. As a conventional PKC isoform, it requires calcium ions, diacylglycerol, and phospholipids for activation. PKCα plays a crucial role in regulating diverse cellular processes, including cell proliferation, apoptosis, and cardiac function. It acts downstream of various receptors, phosphorylating protein targets to modulate signaling pathways. Due to its involvement in major disease processes, such as cancer and cardiac diseases, PKCα is an active area of research for therapeutic targeting.
- Other names
- PKC-alphaprotein kinase C
02
Mechanism of action
Pharmacological inhibition or modulation of PKCα activity.
03
Biological functions
Cell proliferationCell growth arrestCell adhesionCell transformationApoptosisDifferentiationCardiac contractilityCalcium handling
04
Disease associations
Cancer progressionCancer regulationCardiac diseasesImmune responses
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