Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1)
- Target
- PACSIN1
- Molecular classification
- Cytoskeletal protein, Intracellular trafficking protein, F-BAR (Fes/CIP4 homology-Bin/amphiphysin/Rvs) domain protein, Scaffold protein, Membrane deformation protein
01
Overview
Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1), also known as syndapin-1, is a neuronal scaffolding protein that plays a critical role in membrane tubulation, endocytosis, and vesicle-mediated trafficking. By binding to dynamin family GTPases and actin cytoskeleton regulators, PACSIN1 facilitates synaptic vesicle recycling, receptor trafficking (notably AMPA and NMDA receptors), and contributes to synaptic plasticity and morphogenesis[1][2][3][4][5]. Its F-BAR domain mediates membrane curvature and tubulation, while the SH3 domain enables protein-protein interactions essential for endocytosis and actin regulation[2][5]. Although PACSIN1 is connected to several neurological and developmental disorders, it is not classically considered a therapeutic drug target but is widely studied in the context of neuronal physiology and disease[1][2][3].
- Other names
- Syndapin-1syndapin ISDPIKIAA1379PACN1protein kinase C and casein kinase substrate in neurons 1
02
Biological functions
Membrane tubulationEndocytosis and exocytosisSynaptic vesicle recyclingRegulation of actin and microtubule cytoskeletonNeurite morphogenesis (including regulation of neurite length and branching)Receptor trafficking (notably AMPA, NMDA, and glycine receptors)Synaptic plasticity
03
Disease associations
Neurodevelopmental disorder (e.g., Spondylometaphyseal dysplasia, Kozlowski Type)HyperekplexiaSchizophrenia (genetic association and mouse models)Potential role in neurodegenerative disease (connected to synaptic function and plasticity, though not directly established as a therapeutic target)
Beyond the preview
Go deeper on Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1).