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Target intelligence / Profile preview
Protein Kinase C Beta (PKCβ)
- Target
- PKCβ
- Molecular classification
- Enzyme, Serine/threonine-specific kinase, Protein Kinase C family
01
Overview
Protein kinase C beta (PKCβ) is a serine/threonine-specific kinase activated by calcium and diacylglycerol (DAG). It is a member of the protein kinase C (PKC) family. PKCβ participates in numerous cellular processes, including B cell activation, apoptosis, endothelial cell proliferation and intestinal sugar absorption. PKCβ has been implicated in tumorigenesis, making it a target for cancer therapy. Selective inhibitors like enzastaurin have shown efficacy against tumor growth/angiogenesis, and ruboxistaurin is under clinical investigation for diabetic complications.
- Other names
- PKCBPRKCBPKC-beta
02
Mechanism of action
Selective inhibition of PKCβ
03
Biological functions
B cell activationInduction of apoptosisEndothelial cell proliferationIntestinal sugar absorptionRegulation of neuronal functionsSignal transduction
04
Disease associations
TumorigenesisCancerDiabetic complications
05
Interacting drugs
Enzastaurin
1 more in the full profile.
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