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Protein kinase C beta 1 (None)

Target: None
Molecular classification: Enzyme, Serine/threonine protein kinases

Overview

Protein kinase C beta 1 (PKCβ1) is a serine/threonine-specific kinase that belongs to the PKC family. It is activated by calcium and diacylglycerol (DAG) and plays a crucial role in various cellular processes, including B-cell activation, apoptosis, endothelial cell proliferation, and regulation of NHE-1 activity. PKCβ1 has been implicated in immune dysfunctions and neurological conditions such as autism spectrum disorder, and it serves as a major receptor for tumor-promoting phorbol esters.

Other names: PKCβ1PKC beta type (isoform 1)

Mechanism of action

Inhibition of PKCβ1 activity

Biological functions

B-cell activationApoptosis inductionEndothelial cell proliferationIntestinal sugar absorptionRegulation of NHE-1 activitySignal transduction

Disease associations

Immune dysfunctionsNeurological conditionsAutism spectrum disorderCancer

Interacting drugs

Go6976

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