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Protein Kinase C beta I (None)

Target: None
Molecular classification: Enzyme, Serine/threonine-specific protein kinase

Overview

Protein kinase C beta I (PKCβI) is an isoform of the protein kinase C (PKC) family, which are serine/threonine-specific kinases activated by calcium and diacylglycerol (DAG). It plays a central role in diverse cellular signaling pathways, with distinct expression profiles and functional roles, most notably in B-cell activation via the NF-kappa-B pathway, as well as apoptosis and endothelial cell proliferation. Several small-molecule inhibitors targeting PKCβ have been developed or are under investigation as therapeutic agents.

Other names: PKCβIPRKCB

Mechanism of action

Inhibition of PKCβI kinase activity.

Biological functions

Signal transductionB-cell activationNF-kappa-B pathway regulationApoptosisEndothelial cell proliferationTranscriptional regulationCalcium signaling

Disease associations

CancerImmune disordersAutism (possible association)

Interacting drugs

Gö6976

2 more in the full profile.

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