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Protein Kinase C delta (PKCδ)
- Target
- PKCδ
- Molecular classification
- Enzyme, Serine/threonine protein kinase, Novel PKC
01
Overview
Protein kinase C delta (PKCδ) is a member of the protein kinase C (PKC) family of serine/threonine kinases that regulates cell proliferation, differentiation, and apoptosis. As a novel PKC isoform, PKCδ is activated by diacylglycerol (DAG) or phorbol esters in a calcium-independent manner. It is implicated in various cellular processes, including B cell signaling, DNA damage response, and platelet function. PKCδ is overexpressed in several cancers and can act as a negative regulator of cellular senescence in colorectal cancer. Targeted inhibition of PKCδ holds therapeutic potential in certain cancers.
- Other names
- PKCDPRKCD
02
Mechanism of action
Inhibition of PKCδ activity, induction of cellular senescence
03
Biological functions
Cell proliferationCell differentiationApoptosisB cell signalingDNA damage responseRegulation of platelet function
04
Disease associations
CancerColorectal cancer
05
Safety considerations
Potential for off-target effects due to PKC family similarityContext-dependent effects (pro- or anti-apoptotic)Splice variant specific effects
06
Interacting drugs
Phorbol esters
1 more in the full profile.
07
Biomarkers
PKCδ expression levels in tumor tissuep21 expression
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