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Target intelligence / Profile preview
Protein kinase C delta isozyme (PKCδ)
- Target
- PKCδ
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase, Protein kinase C, Novel protein kinase Cs
01
Overview
Protein kinase C delta (PKCδ) is a member of the protein kinase C (PKC) family, which consists of serine/threonine kinases involved in regulating diverse cellular processes. PKCδ belongs to the "novel" subfamily of PKCs, which are characterized by their activation through diacylglycerol (DAG) but not calcium ions. It plays critical roles in cell growth, differentiation, proliferation, and apoptosis, and participates in cellular responses to oxidative stress. Altered PKCδ function has been implicated in several human diseases including cancer, stroke, ischemic heart disease, diabetes mellitus, neurodegenerative disorders, and sepsis.
- Other names
- nPKC-deltaPKCd
02
Mechanism of action
Protein phosphorylation; modulation of protein-protein interactions
03
Biological functions
Regulation of cell growthCell differentiationCell proliferationApoptosis regulationCell cycle progressionCell divisionResponse to oxidative stressSignal transduction
04
Disease associations
CancerStrokeIschemic heart diseaseDiabetes mellitusNeurodegenerative disordersSepsis
05
Safety considerations
Context-dependent pro-apoptotic or anti-apoptotic effectsLack of clinically approved selective drugs
06
Interacting drugs
δV1–1
3 more in the full profile.
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