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Target intelligence / Profile preview
Protein kinase C eta (PKCη)
- Target
- PKCη
- Molecular classification
- Enzyme, Protein Kinase, Serine/threonine-protein kinase
01
Overview
Protein kinase C eta (PKCη) is a serine/threonine-specific kinase involved in diverse cellular signaling pathways. It is a member of the protein kinase C (PKC) family, and is unique due to its distinct regulatory mechanisms and tissue distribution. It plays a role in cell proliferation, differentiation, cell death, and keratinocyte biology, and has been implicated in chemoresistance in several cancers. Its role in cancer is complex, with overexpression promoting tumorigenesis in some cancers, while loss increases susceptibility in others.
- Other names
- PRKCH
02
Mechanism of action
Phosphorylation of target proteins
03
Biological functions
Signal transductionCell proliferationCell differentiationCell deathKeratinocyte differentiationCell cycle regulationImmune response regulationTissue homeostasis
04
Disease associations
Cancer
05
Safety considerations
Complex and contradictory roles in cancer; targeting may have unpredictable effects depending on context.
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