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Protein kinase C gamma (PKCγ)
- Target
- PKCγ
- Molecular classification
- Enzyme, AGC Ser/Thr protein kinase family, Classical/conventional PKCs (cPKCs)
01
Overview
Protein kinase C gamma (PKCγ) is a neuron-specific member of the protein kinase C (PKC) family, encoded by the PRKCG gene. It plays critical roles in neuronal signal transduction pathways and is essential for synaptic plasticity processes such as long-term potentiation (LTP) and long-term depression (LTD). Mutations or defects are linked with spinocerebellar ataxia type 14 (SCA14), a neurodegenerative disorder.
- Other names
- PRKCG
02
Mechanism of action
Phosphorylation of downstream targets upon activation by Ca²⁺, DAG, phosphatidylserine, and phosphorylation
03
Biological functions
Neuronal signal transductionSynaptic plasticityLong-term potentiation (LTP)Long-term depression (LTD)Motor coordinationOpioid receptor signaling modulationGABA signaling modulationNeuroplasticity networks essential for learning/memory formation
04
Disease associations
Spinocerebellar ataxia type 14 (SCA14)Neurodegenerative diseaseRetinitis pigmentosaParkinsonian syndromesNeuropathic pain
05
Safety considerations
Involvement in neurodegenerative disordersPotential for off-target effects due to broad kinase activity
06
Interacting drugs
Ethanol
2 more in the full profile.
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