Protein kinase C isoforms and other kinases (PKC and other kinases)

Protein kinase C (PKC) isoforms and other kinases refers to a broad and heterogeneous group of enzymes rather than a single, specific therapeutic target. The PKC family consists of multiple serine/threonine kinases—classified into conventional, novel, and atypical subfamilies—that play pivotal roles in signal transduction pathways regulating cell growth, differentiation, and survival [1]. In drug discovery, this terminology is frequently used to describe the off-target profile or broad selectivity of multi-kinase inhibitors, such as staurosporine derivatives, which may interact with various members of the kinome beyond their primary target [2, 3]. While individual PKC isoforms are investigated as targets for cancer, diabetic complications, and inflammatory diseases, the simultaneous inhibition of other kinases often leads to significant toxicity}

Other names

PKC familyProtein kinase CSerine/threonine-protein kinasesKinome

Inhibition of kinase catalytic activity through ATP-competitive binding or modulation of regulatory domains.