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Target intelligence / Profile preview
Protein kinase CK1α (CK1α)
- Target
- CK1α
- Molecular classification
- Enzyme, Serine/threonine protein kinase
01
Overview
Protein kinase CK1α (Casein kinase 1 alpha) is a serine/threonine-specific protein kinase and a member of the casein kinase 1 (CK1) family. It plays critical roles in numerous cellular processes, including Wnt/β-catenin signaling, cell cycle progression, apoptosis regulation, and membrane trafficking. CK1α has been implicated in cancer progression and neurodegenerative diseases, making it an attractive target for therapeutic intervention.
- Other names
- Casein kinase 1 alphaCSNK1A1
02
Mechanism of action
CK1α inhibitors (target-specific compounds)
03
Biological functions
Wnt/β-catenin signalingCell cycle progressionMitosisApoptosis regulationMembrane traffickingChromosome segregationAutophagyMetabolismDifferentiation during developmentCircadian rhythm regulationImmune response
04
Disease associations
Cancer progression (prostate, breast, ovarian, colorectal cancers)Neurodegenerative diseases
05
Safety considerations
Off-target effects due to the wide range of substratesPotential for disrupting multiple cellular processes
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