Protein Kinase G Pathway Activation via cGMP Elevation Leading to Apoptosis Induction (PKG Pathway Activation)

Activation of the protein kinase G (PKG) pathway via elevation of cyclic guanosine monophosphate (cGMP) aims to induce apoptosis in neoplastic cells. This pathway is initiated by increased intracellular cGMP, which activates PKG. PKG then phosphorylates downstream targets, regulating cell proliferation and survival, often leading to growth inhibition or programmed cell death in certain cancer types. Strategies to activate this pathway include using NO donors, natriuretic peptides, guanylyl cyclase activators, and PDE5 inhibitors.

Other names

cGMP/PKG Pathway ActivationCyclic GMP-dependent Protein Kinase ActivationPKG SignalingcGMP Signaling

Elevation of intracellular cGMP levels activates Protein Kinase G (PKG), leading to phosphorylation of downstream targets involved in cell proliferation and survival, ultimately resulting in apoptosis in neoplastic cells.