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Target intelligence / Profile preview
Protein Kinase N3 (PKN3)
- Target
- PKN3
- Molecular classification
- Enzyme, Serine/threonine-protein kinase
01
Overview
Protein kinase N3 (PKN3) is a serine/threonine protein kinase that belongs to the protein kinase C-related family. It functions as an effector molecule downstream of activated phosphoinositide 3-kinase (PI3K) and plays significant roles in cell signaling pathways related to cancer progression, angiogenesis, cytoskeletal remodeling, and bone resorption. Its expression is notable in prostate tumors and various cancer cell lines but is not detected at significant levels in most adult tissues under normal conditions.
- Other names
- UTDP4-1protein kinase N3
02
Mechanism of action
As a kinase, the mechanism of action for drugs targeting PKN3 would be kinase inhibition.
03
Biological functions
AngiogenesisTumor metastasisActin/adherens junction remodelingBone resorptionCell proliferationSignal transductionRegulation of cytoskeleton
04
Disease associations
CancerNonarteritic anterior ischemic optic neuropathyGastrointestinal disordersMetabolic bone diseaseOsteoporosisRheumatoid arthritis
05
Safety considerations
Inhibition of PKN3 may affect normal bone homeostasis.Potential for off-target effects due to kinase family similarities.
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