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Protein kinase Plasmodium falciparum CLK3 (PfCLK3)
- Target
- PfCLK3
- Molecular classification
- Protein Kinase, Cyclin-dependent like kinases (CLKs), Serine/Threonine Kinase
01
Overview
Protein kinase PfCLK3 is an essential regulator of RNA splicing required for malaria parasite viability at multiple life stages—including blood, liver, and sexual forms—and represents a highly promising target for next-generation antimalarials with both treatment and transmission-blocking capabilities.
- Other names
- PF3D7_1114700Plasmodium falciparum Cyclin-dependent Like Kinase 3
02
Mechanism of action
Inhibition of PfCLK3 leads to impaired phosphorylation of SR proteins, disrupted mRNA processing/splicing, and downregulation of essential genes.
03
Biological functions
Regulation of RNA splicingPhosphorylation of SR proteinsmRNA processingSpliceosome assembly
04
Disease associations
InfectionMalaria
05
Safety considerations
Potential for off-target effects due to similarity to human CLKs/SRPKsDevelopment of resistance
06
Interacting drugs
TCMDC-135051
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