Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 (PCMTD2)

Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 (PCMTD2) is a protein encoded by the PCMTD2 gene in humans. The protein contains domains homologous to the methyltransferase PCMT1, but it likely does not possess methyltransferase enzymatic activity under normal conditions. Instead, PCMTD2, similar to its paralog PCMTD1, features additional C-terminal domains containing SOCS-box motifs (BC-box and Cul-box) that suggest a role as a substrate adaptor for Cullin-RING E3 ubiquitin ligase complexes, such as ECS (Elongin BC-CUL5-SOCS-box). Through these motifs, PCMTD2 may be involved in recognizing isoaspartate-damaged proteins and targeting them for ubiquitylation and degradation, potentially contributing to cellular protein quality control. Additionally, PCMTD2 has been found to be essential for the survival of pro-B cells during V(D)J recombination, likely through a role in mitigating cellular stress from protein damage. There is currently no strong evidence that PCMTD2 is a direct therapeutic target, receptor, enzyme, or transporter, and its interactions with drugs or relevance as a biomarker are undocumented as of the most recent sources[2][3][4].

Other names

PCMTD2C20orf36FLJ10883protein-L-isoaspartate O-methyltransferase domain-containing protein 2