Protein lin-52 homolog (LIN52)

Protein lin-52 homolog (LIN52) is a small protein subunit of the MuvB core complex, which is central to the assembly and function of cell cycle-regulatory transcriptional complexes: DREAM (quiescent state gene repression) and MMB/FOXM1-MuvB (mitotic gene activation)[1][2][3][4][5]. LIN52 is responsible for recruiting pocket proteins p107/p130 and B-MYB, controlling dynamic transitions between cell cycle phases. Phosphorylation by DYRK1A at Ser28 on LIN52 triggers DREAM complex formation by enabling specific binding to p107/p130, thus repressing cell cycle genes during cell quiescence[1][3]. When not phosphorylated, LIN52 helps form the MMB complex with B-MYB that activates mitotic gene transcription[1][2]. LIN52 itself acts only within these multi-protein complexes, and there are no known drugs targeting it directly. Dysfunction of the MuvB/DREAM complex, including LIN52, is implicated in cancer through loss of cell cycle checkpoint control and abnormal cell proliferation[1][3][5].

Other names

LIN52Protein lin-52 homologC14orf46c14_5549lin-52 homolog

Not applicable directly; no drugs act on LIN52 itself. Indirect mechanism: Kinase inhibitors (e.g., DYRK1A inhibitors) may modulate DREAM complex assembly by affecting LIN52 phosphorylation[3].