Protein lin-7 homolog C (LIN7C)

Protein lin-7 homolog C (LIN7C) is a scaffold protein that plays a key role in establishing and maintaining the asymmetric distribution of proteins such as channels and receptors at the plasma membrane of polarized cells, especially in epithelial and neuronal tissues[1][6]. LIN7C is part of membrane-associated multiprotein complexes necessary for proper delivery and recycling of proteins to distinct membrane domains[1][6]. In neurons, it forms complexes with CASK and APBA1, associating with the motor protein KIF17 to transport vesicles containing NMDA receptor subunits along microtubules, ensuring targeting and retention at the postsynaptic density[1][6]. In epithelial cells, LIN7C is vital for localizing proteins such as Kir2 channels, GABA transporters, and ERBB family receptors to the basolateral membrane[1][6]. It interacts with proteins including DLG1, KCNJ12, KCNJ4, and forms tripartite complexes with cellular proteins MPP7 and DLG1, influencing cell polarity and adhesion[3][5]. Disruption of LIN7C function has been associated with diseases involving loss of cell polarity, including certain cancers and neurodevelopmental disorders[1]. LIN7C is not currently recognized as a direct therapeutic target, receptor, or enzyme, and there is no specific drug targeting LIN7C at present. However, its role in multi-protein complexes and disease association makes it of biological and potentially clinical interest.

Other names

Lin-7CMALS3VELI3MALS-3Veli-3FLJ11215Mammalian lin-seven protein 3Vertebrate lin-7 homolog 3LIN-7 protein 3crumbs cell polarity complex componentveli-3lin-7 homolog Cprotein lin-7 homolog CLIN-7CLIN-7-Cmammalian LIN-7 3vertebrate LIN7 homolog 3