Protein LTV1 homolog (LTV1)

Protein LTV1 homolog (LTV1) is a conserved, non-ribosomal factor essential for the biogenesis of the eukaryotic 40S ribosomal subunit[1][2][3]. LTV1 functions as an assembly factor, facilitating the incorporation of ribosomal proteins Rps3 and Rps10 during the maturation of the 40S subunit, and includes a leucine-rich nuclear export signal at its C-terminus[1][3]. LTV1 shuttles between the nucleus and cytoplasm and interacts with both ribosomal protein S3 (RpS3) and the stress-responsive chaperone Yar1[2][3]. It is not directly a therapeutic target, enzyme, or receptor, but is crucial for fundamental processes such as ribosome assembly, cell proliferation, and organogenesis, especially during embryonic development[1][3]. Loss of LTV1 function leads to defects in ribosome biogenesis, resulting in developmental abnormalities, particularly affecting the digestive system and blood cell production (hematopoiesis), and is linked to ribosomopathies in humans and animal models[1]. LTV1 deficiency alters cellular sensitivity to stress and protein synthesis inhibitors, linking ribosome assembly to environmental stress response pathways[2]. No current drugs are known to directly target LTV1, and it is not used as a biomarker or therapeutic target in clinical practice.

Other names

Protein LTV1 homologLTV1C6orf93FLJ14909dJ468K18.4IPHAK