Protein mago nashi homolog B (MAGOHB)

Protein mago nashi homolog B (MAGOHB) is a core member of the exon junction complex (EJC), a multi-protein assembly that binds to mRNA near exon-exon junctions following splicing[1][2][4]. MAGOHB, together with its paralog MAGOH, partners with other EJC core proteins (eIF4A3, Y14) to regulate post-transcriptional processes, including mRNA export, localization, translation, and notably nonsense-mediated decay (NMD) to eliminate faulty mRNAs[1][2][4]. High MAGOHB expression is seen in malignant tumors such as glioblastoma and melanoma, where it is implicated in enhanced cell proliferation and survival. Knockdown studies indicate that depletion of MAGOHB (alone or combined with MAGOH) disrupts splicing precision, impairs NMD, and promotes apoptosis, suggesting that the EJC’s RNA surveillance role is critical for rapidly dividing cells[1][4]. MAGOHB is not typically classified as a classic drug target (receptor, enzyme, ion channel), but its fundamental roles in RNA biology and cancer make it a protein of interest for basic research and potential future interventions[1][2][4].

Other names

MAGOH2MGN2mago homolog Bmago-nashi homolog Bprotein mago nashi homolog 2magohMAGOFLJ10292

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