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Protein MAK16 homolog (MAK16)

Target: MAK16
Molecular classification: RNA binding protein, Ribosome assembly factor, Nucleolar protein

Overview

Protein MAK16 homolog is an essential nucleolar RNA-binding protein required for ribosome assembly, particularly the maturation of 5.8S rRNA and large ribosomal subunit rRNA[1][2][3]. Its deficiency leads to cell cycle arrest and impaired ribosome production, especially demonstrated in yeast. In humans, altered MAK16 expression has biomarker potential in cancer and autoimmunity, but currently there is no evidence it serves as a therapeutic drug target[1][2][3].

Other names: MAK16LRBM13MAK16 homologRNA binding motif protein 13NNP78

Biological functions

Ribosome biogenesisrRNA maturation (especially 5.8S rRNA and LSU-rRNA)Cell cycle progression and regulationPossibly maintenance of viral double-stranded RNA particles (yeast)

Disease associations

Cancer (as a putative biomarker in colorectal cancer)Autoimmune disease (autoantibodies found in lupus diagnostic panels)Possible adaptation to environmental arsenic exposure (genetic signals)

Biomarkers

Differential MAK16 expression as prognostic in colorectal cancerAutoantibodies to MAK16 detectable in systemic lupus erythematosus

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