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Protein Palmitoylation Enzymes (PATs/zDHHCs & APTs)
- Target
- PATs/zDHHCs & APTs
- Molecular classification
- Enzyme, Protein Acyltransferase, Hydrolase, Membrane protein
01
Overview
Protein palmitoylation enzymes, primarily the zDHHC family and APTs, catalyze the addition and removal of palmitate to proteins, respectively. This modification impacts protein localization, trafficking, and signaling. They are therapeutic targets in cancer and other diseases.
- Other names
- Palmitoyl AcyltransferaseszDHHC proteinsAcyl Protein Thioesterases
02
Mechanism of action
Inhibition of palmitoylation or depalmitoylation
03
Biological functions
Protein palmitoylationMembrane anchoringProtein traffickingSignal modulationRegulation of protein stabilityRegulation of protein-protein interactions
04
Disease associations
Cancer progressionCancer suppressionImmune evasionNeurodegenerative disordersViral infection
05
Safety considerations
Off-target effectsSide effects associated with SCD1 inhibitors
06
Interacting drugs
2-bromopalmitate (2BP)
3 more in the full profile.
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