Protein pelota homolog (PELO)

Protein pelota homolog (PELO) is a highly conserved cytoplasmic protein, encoded by the PELO gene in humans[1][9]. It belongs to a family of proteins involved in the recognition and rescue of stalled ribosomes during translation, in a process known as ribosome quality control or No-Go Decay (NGD)[2][5][7]. PELO functions with partners such as HBS1L and ABCE1 to dismantle aberrant ribosome complexes, release nascent polypeptide-tRNA, and promote ribosome recycling independent of stop codon recognition[6]. In biological systems, PELO plays important roles in translational surveillance, cell cycle control, spermatogenesis, and adult stem cell self-renewal[1][3][4]. Loss of PELO function leads to defects in spermatogenesis and meiotic arrest in model organisms and can dysregulate translation of proteins critical in hematopoiesis (e.g., the C/EBPα isoform in myeloid cells), connecting PELO indirectly to cancer biology[4]. There is no current evidence that PELO is a direct therapeutic target or that drugs interact with it, and no established biomarker or specific safety concern for its targeting in humans.

Other names

PelotaDom34 homologCGI-17PELOTAPELO homologmRNA surveillance and ribosome rescue factor PELO