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Target intelligence / Profile preview
Protein Phosphatase 1 (PP1)
- Target
- PP1
- Molecular classification
- Enzyme, Ser/Thr protein phosphatase
01
Overview
Protein phosphatase 1 (PP1) is a highly conserved and widely expressed serine/threonine-specific phosphatase in eukaryotic cells. It is responsible for catalyzing the dephosphorylation of more than half of all phosphoserine/threonine residues, making it one of the most significant protein phosphatases in cellular regulation. PP1 regulates diverse essential processes through forming distinct holoenzymes with over 200 known regulatory partners, allowing precise spatial-temporal control over dephosphorylation events within cells.
02
Mechanism of action
Modulation of PP1 activity through targeting holoenzyme complexes or interactions between PP1c and PIPs.
03
Biological functions
Glycogen metabolismMuscle contractionCell cycle progressionMitosisNeuronal activitiesRNA splicingApoptosisProtein synthesisSignal transduction
04
Disease associations
CancerDiabetesCardiac dysfunctionsNeurodegenerative disorders
05
Safety considerations
Ubiquity of PP1 requires selective targeting of specific holoenzyme complexes to avoid broad inhibition of cellular dephosphorylation reactions.
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