Protein phosphatase 1 regulatory inhibitor subunit 14D (PPP1R14D)

PPP1R14D (Protein phosphatase 1 regulatory inhibitor subunit 14D) is a regulatory protein that inhibits protein phosphatase 1 (PP1) when phosphorylated, serving as a molecular switch for the regulation of PP1 activity. By controlling the reversible phosphorylation of serine/threonine residues, PPP1R14D modulates essential signal transduction pathways. It is found with highest expression in the gastrointestinal tract and brain (hence, some aliases), and is notably upregulated in lung adenocarcinoma, where it drives cancer cell proliferation, migration, and invasion via the PKCα/BRAF/MEK/ERK signaling pathway. Dysregulation links PPP1R14D with poor cancer prognosis, identifying it as a potential biomarker and therapeutic target. PPP1R14D belongs to the family of protein phosphatase 1 regulatory subunits, and its function depends on phosphorylation events, primarily by PKC, making it an important nexus in phosphorylation-dependent cellular control[1][2][5].

Other names

Protein phosphatase 1 regulatory subunit 14DGBPIGBPI-1CPI17-likeFLJ20251MGC119014MGC119016Gastrointestinal and brain-specific PP1-inhibitory protein 1Gut and brain phosphatase inhibitor 1PKC-dependent PP1 inhibitory proteinGBPI1

Drugs or agents that modulate PPP1R14D likely act by modifying its phosphorylation state, thus altering its inhibitory effect on PP1 activity and downstream signaling pathways[1][2].