Protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 2 (PPP1R2P2)

Protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 2 (PPP1R2P2) is a **processed pseudogene** found in the human genome, highly similar in sequence to the parental PPP1R2 gene (which encodes Inhibitor-2, a known regulator of protein phosphatase 1) [1][3][5]. Unlike the functional protein-coding gene PPP1R2, pseudogene 2 (PPP1R2P2) is generally regarded as **non-coding**, disrupted by multiple missense mutations that prevent stable protein production in humans and other primates [1]. While occasional **transcription of PPP1R2P2 is detected at the RNA level** in specific tissues (notably testis and prostate), there is **no evidence of sustained translation or functional protein production** [1]. Like some pseudogenes, PPP1R2P2 might hypothetically participate in gene regulation at the RNA level (e.g., as a competing endogenous RNA), but this has not been established for this locus [1]. PPP1R2P2 does **not encode a receptor, enzyme, transporter, or any canonical drug target**, is not implicated in major cellular signaling pathways or disease roles, and has **no known drug interactions** [1][3][5]. Its presence in experimental RNA data is more likely due to genomic artifacts or unspecific transcription [1].

Other names

PPP1R2P2IPP-2-related pseudogeneprotein phosphatase 1, regulatory (inhibitor) subunit 2, pseudogene

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