Protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 4 (PPP1R2P4)

Protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 4 (PPP1R2P4) is a member of a family of processed pseudogenes derived from the functional gene PPP1R2, which encodes a key regulatory inhibitor of protein phosphatase 1 (PP1)[1][2][3]. As a pseudogene, PPP1R2P4 does not encode a functional protein and lacks documented biological or disease relevance. Such pseudogenes typically arise from retrotransposition events, resulting in non-functional copies dispersed in the genome[1][3]. There is no evidence that PPP1R2P4 is expressed or confers any functional regulatory capability on protein phosphatase 1 activity. Key Notes: - *PPP1R2*, the parental functional gene, is a genuine regulatory inhibitor of PP1 and has established biological and disease relevance, but PPP1R2P4 does not share these roles. - Other pseudogenes in this family (e.g., PPP1R2P1, PPP1R2P3, PPP1R2P9) may retain some capacity for expression or truncated regulatory activity, but PPP1R2P4 has no evidence of functional output or significance[1]. PPP1R2P4 is therefore **not a druggable or disease-relevant molecular target**, and inclusion as a therapeutic target would be inaccurate. If your intent is to focus on the biologically active regulator, consider the parent gene/protein, **Protein phosphatase 1 regulatory inhibitor subunit 2 (PPP1R2)**[1][5].