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Protein Phosphatase 1 Regulatory Subunit 15A (None)
- Target
- None
- Molecular classification
- Regulatory Subunit, Protein Phosphatase Regulator
01
Overview
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A), also known as GADD34, is a regulator of protein phosphatase 1 (PP1) activity. It plays a crucial role in the integrated stress response by promoting the dephosphorylation of eIF2α, which restores translation after stress-induced inhibition. PPP1R15A is involved in autophagy, apoptosis, and cell cycle regulation, particularly in response to cellular stress conditions such as ER stress, DNA damage, and nutrient deprivation. Its dysregulation is implicated in cancer.
- Other names
- PPP1R15AGADD34Growth Arrest and DNA-Damage-Inducible Protein 34Protein Phosphatase 1 Regulatory (Inhibitor) Subunit 15A
02
Mechanism of action
Acts as a regulatory subunit for protein phosphatase 1 (PP1), directing its activity towards specific substrates like eIF2α.
03
Biological functions
Regulation of PP1 activityeIF2α dephosphorylationTranslation modulationStress responseAutophagy regulationApoptosis modulation
04
Disease associations
CancerER stress-related diseases
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